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KMID : 0352719920160030183
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Journal of Ginseng Research
1992 Volume.16 No. 3 p.183 ~ p.189
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Neurochemical Studies of Standardized Ginseng Extract G115 on the Central Dopaminergic Activity (II)
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Abstract
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Effects of the standardized ginseng ex(?) (G115) on the central monoaminergic systems were investigated in comparison with that of haloperidol in rats. Immediately after sacrificed by decapitation, the striata and frontal cortex were removed.
Concentrations of the monoamines dopamine and serotonin and metabolites were determined by HPLC-EC G115 increased the concentration of 5-HIAA and DOPAC/DA ratio in striatum. However. dopaminergic neuronal activities were not affected by G115 that
decreased the concentrations of 5-HT and 5-HIAA in frontal cortex. G115 in combination with apomorphine significantly increased the concentration of DA and 5-HT but decreased the DO-PAC/DA ratio and 5-HIAA/5-HT ratio only in frontal cortex. These
results suggest that G115 like HPD inhibits the activity of nigrostriatal dopamine neuron in striatum. However, unlike HPD it activates central monoaminergic neuron activity in frontal cortex.
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